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KMID : 0363120080210010051
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Korean Journal of Pain
2008 Volume.21 No. 1 p.51 ~ p.56
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The Effect of Preoperative Dexamethasone Administration, according to Age and Gender on Postoperative Pain in Patients who Undergo Laparoscopic Choelecystectomy
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Lee Cheol
Kim Tai-Yo
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Abstract
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Background: Preoperative dexamethasone improves the surgical outcome after laparoscopic cholecystectomy
(LC). The purpose of this study was to determine the effect of preoperative dexamethasone on the postoperative
pain according to age and gender in patients who undergo LC.
Methods: In this double blind prospective study, 400 patients, males or females ≤ 45 yr and males or females
≥ 65 yr (n = 50 in each of eight groups) who undergoing LC were randomized to receive dexamethasone 8
mg (5 ml) or saline 5 ml intravenously 100 minutes before their operation. Postoperative pain was assessed
on a visual analog scale (VAS) at 1, 6, 12, and 24 hour, and the time to administering the first postoperative
analgesics was recorded.
Results: Dexamethasone was administered without consideration for age and gender, and it reduced the
postoperative pain VAS score at 1, 6, and 12 hours, and the opioid analgesic requirement, but there was no
significant difference between administering saline or dexamethasone in the same gender and age groups.
Females ≤ 45 yr who were administered saline had the most pain sensitivity and males ≥ 65 yr who were
administered dexamethasone had the least pain sensitivity.
Conclusions: Preoperative dexamethasone reduces the pain intensity and opioid consumption, but does not
reduce the pain intensity, according to age and gender in the patients undergoing LC. As a result, preoperative
dexamethasone should be considered for routine use for patients who are undergoing laparoscopic cholecystectomy.
(Korean J Pain 2008; 21: 51?56)
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KEYWORD
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age, dexamethasone, laparoscopic cholecystectomy, postoperative pain, sex
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